METHOD FOR DIAGNOSING PLACENTA INGROWTH INTO UTERINE WALL IN WOMEN WITH PLACENTA PREVIA

摘要

FIELD: medicine; obstetrics and gynecology.;SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology; it can be used for diagnosing placenta ingrowth into the uterine wall in women with placenta previa. Immunoassay analysis of the blood serum of a pregnant woman is conducted. In a complex, the level of pregnancy-associated plasma protein-A (hereinafter – PAPP-A), expressed in multiple of median (hereinafter – MoM), is determined in 11-13 weeks of pregnancy; the concentration of soluble fms-like tyrosine kinase-1 (hereinafter – sFlt-1) in pg/ml, placenta growth factor (hereinafter – PlGF) in pg/ml is determined once in the 3rd trimester of pregnancy. A coefficient C1 – the ratio of sFlt-1 concentration to PlGF concentration – is calculated. The, an indicator P is determined as the ratio of PAPP-A level expressed in MoM to the coefficient C1. A coefficient C2 is determined as a number of caesarean sections (N CS) in a pregnant woman in the anamnesis plus conventional unit (+1). Then, the presence of placenta ingrowth (PC) is determined as the result of multiplication of the sum of P and conventional unit (+1) by C2: PC = (P+1) × C2. When PC is more than 3.30, the presence of placenta ingrowth is determined.;EFFECT: method provides for the possibility of increasing the specificity of prediction of placenta ingrowth due to a complex assessment of biomarkers of pathological placentation of the 1st and the 3rd trimesters of pregnancy, as well as increasing the reproduction of the results due to the use of indicators independent of variety of measurements performed on specific equipment.;1 cl, 3 tbl, 2 ex