Nucleus nucleus cell master regulator Differentiation inducer containing transcription factor, method for producing induced nucleus pulposus cell, and use of induced nucleus pulposus cell

摘要

The present invention provides a reproducible means capable of producing an activated nucleus pulposus phenotype from a desired cell, such as terminally differentiated cells or pluripotent or pluripotent stem cells. The present invention relates to at least two transcription factors selected from the group consisting of Brachyury (T), SRY-box6 (SOX6) and Forkhead Box Q1 (FOXQ1), or genes of their homologs (nucleus nucleus cell master regulator transcription factors). Provided is a differentiation inducer containing an effective amount of the product. [Selection diagram] None