首页>
外国专利>
NEOANTIGEN IDENTIFICATION USING HOTSPOTS
NEOANTIGEN IDENTIFICATION USING HOTSPOTS
展开▼
机译:使用热点识别新抗原
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method for identifying neoantigens that are likely to be presented on a surface of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequence of each of the neoantigens is associated with one or more k-mer blocks of a plurality of k-mer blocks of the nucleotide sequencing data of the subject; The peptide sequences and the associated k-mer blocks are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by an MHC allele on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods.
展开▼