首页> 外国专利> Nucleic acid inhibiting expression of the MEX3B gene, MEX3B gene expression inhibitor, method for inhibiting MEX3B gene expression, and prophylactic or therapeutic agent for disease caused by MEX3B gene expression

Nucleic acid inhibiting expression of the MEX3B gene, MEX3B gene expression inhibitor, method for inhibiting MEX3B gene expression, and prophylactic or therapeutic agent for disease caused by MEX3B gene expression

机译:抑制MEX3B基因表达的核酸,MEX3B基因表达抑制剂,抑制MEX3B基因表达的方法,以及预防或治疗由MEX3B基因表达引起的疾病的药物

摘要

A nucleic acid which can inhibit expression of the MEX3B gene with low cytotoxicity as a side effect, an MEX3B gene expression inhibitor which contains said nucleic acid, a method for inhibiting MEX3B gene expression, and a prophylactic or therapeutic agent for disease caused by MEX3B gene expression are provided.;This nucleic acid, which inhibits the expression of the MEX3B gene, is an antisense oligonucleotide having a sequence complementary to an oligonucleotide that contains at least 10 contiguous nucleotides in an untranslated region in an exon of the MEX3B gene, ora double-stranded RNA including at least 20 contiguous nucleotides in the aforementioned untranslated region, or DNA encoding said double-stranded RNA.
机译:本发明提供了一种可抑制作为副作用的低细胞毒性MEX3B基因表达的核酸、含有所述核酸的MEX3B基因表达抑制剂、抑制MEX3B基因表达的方法以及对由MEX3B基因表达引起的疾病的预防或治疗剂。;这种抑制MEX3B基因表达的核酸是一种反义寡核苷酸,其序列与在MEX3B基因外显子的一个非翻译区中含有至少10个连续核苷酸的寡核苷酸互补,或在上述非翻译区中含有至少20个连续核苷酸的双链RNA,或者DNA编码的双链RNA。

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