METHOD FOR PRODUCING CARDIAC MUSCLE STEM/PRECURSOR CELLS AND METHOD FOR INHIBITING MYOCARDIAL FIBROSIS

摘要

[Problem] To provide a method for efficiently reprogramming mature and immature cardiac muscle cells into cardiac muscle stem/precursor cells without involving genetic modification, and/or for inhibiting fibrosis. [Solution] According to the present invention, cardiac muscle stem/precursor cells can be maintained by culturing primary cardiac muscle cells in the presence of a ROCK inhibitor. Furthermore, fibrosis is inhibited by causing cardiac muscle cells cultured in the presence of these low-molecular-weight compounds, or exosomes or celectomes derived from the cardiac muscle cells, to act on cardiac fibroblasts.