COMBINATION OF ADOPTIVE CELL THERAPY AND CHEMOTHERAPY FOR ACUTE MYELOID LEUKEMIA

摘要

Disclosed here are methods of treatment of cancers by administering autologous tumor infiltrating lymphocytes optionally in combination with chemotherapeutic and immunotherapeutic agents. Methods include treating acute myeloid leukemia with a combination of autologous TILs-based adoptive cell therapy and agents, such as a PD-1 inhibitor and a hypomethylating agent. The TILs can be bioengineered to modify the expression of function of a gene or a molecule of interest.