Method for screening material for preventing or treating infertility, subfertility and miscarriage

摘要

The present invention relates to a screening method for a substance for preventing or treating female infertility, infertility and miscarriage. Specifically, C-peptide activates PP1 (protein phosphatase 1) to activate GSK3β (glycogen synthase kinase-3 beta), promotes cellular senescence and suppresses apoptosis of endometrial stromal cells through cross-activation of PP1 and GSK3β, and consequently suppresses decidualization , the process of selecting a substance capable of inhibiting the activity and expression level of PP1 and GSK3β can be usefully used to screen candidates for prevention or treatment of female infertility, infertility and miscarriage.