INHIBITORS OF CYSTEINE PEPTIDASES ISOLATED FROM NATURAL RAW MATERIALS AND USE OF THE INHIBITORS IN MEDICINE AND VETERINARY MEDICINE

摘要

The invention discloses low molecular weight cysteine peptidase inhibitors of natural origin, which are several-amino acid oligopeptides of the molecular weight below 3 kDa, free of salts with a molecular weight below 700 Da, a method for isolation of the same from natural organic material selected from the group consisting of egg whites, casein or milk and homogenates of plants such as knotweed, especially of the species Fallopia japonica, Houtt, mistletoe, soy, pineapple, rice, potatoes and other substances of natural origin, as well as medical (first) use in human and veterinary medicine of the low-molecular cysteine peptidase inhibitors of natural origin, being several-amino acid oligopeptides of the molecular weight below 3 kDa and the knotweed cystatin, as well as their use in manufacturing medicaments useful in prevention and treatment of inflammations associated with overexpression of cysteine peptidase enzymes originating from infecting microorganisms, or with overexpression of cysteine peptidase enzymes, being autogenic cysteine cathepsins in the human body.