BIOSYNTHETIC PRODUCTION OF GAMMA- AND DELTA-LACTONES USING CYTOCHROME P450 ENZYMES HAVING SUBTERMINAL HYDROXYLASE ACTIVITY

摘要

Provided herein are methods for making lactones comprising incubating a cellular system expressing a heterologous cytochrome P450 (CYP450) protein with a medium comprising straight chain fatty acids to produce subterminal hydroxy fatty acids, and incubating a yeast cell culture with the subterminal hydroxy fatty acids to produce lactones.