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METHODS OF TREATING CANCER WITH SIRP ALPHA FC FUSION IN COMBINATION WITH AN IMMUNE CHECKPOINT INHIBITOR
METHODS OF TREATING CANCER WITH SIRP ALPHA FC FUSION IN COMBINATION WITH AN IMMUNE CHECKPOINT INHIBITOR
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机译:SIRPα-FC融合联合免疫检查点抑制剂治疗癌症的方法
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摘要
Provided are methods of treating cancer (e.g., non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), HER2-positive gastric/gastroesophageal junction (GEJ) cancer, de novo or transformed diffuse large B cell lymphoma (DLBCL), or indolent lymphoma) in an individual that comprise administering to the individual (a) a polypeptide comprising a SIRPα D1 domain variant and an Fc domain variant, and (b) an anti-cancer antibody (e.g., an anti-PD1 antibody, anti-HER2 antibody, or an anti-CD20 antibody). Also provided are related kits pharmaceutical compositions.
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