Combination therapy of CC chemokine receptor 9 (CCR9) inhibitor and anti-α4β7 integrin blocking antibody

摘要

PROBLEM TO BE SOLVED: To provide a composition, a method, and a kit for treating an inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need of treatment. The method comprises performing a combination therapy in a patient with IBD comprising a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-a4β7 integrin antibody (such as vedrizumab). include. Also provided herein are kits comprising a CCR9 inhibitor compound and an anti-a4β7 integrin antibody. [Selection diagram] Fig. 4C