Composition for preventing or treating inflammatory macrophage-mediated autoimmune disease comprising exosomes derived from stem cells that are surface-modified to target activated macrophages

摘要

The present invention relates to a composition for the prevention, improvement and treatment of inflammatory macrophage-mediated autoimmune diseases, etc. comprising, as an active ingredient, a stem cell-derived exosome whose surface is modified with a sugar compound to target activated macrophages. The composition according to the present invention can increase the treatment efficiency of various autoimmune diseases, including rheumatoid arthritis, by specifically targeting the activated macrophages. In addition, since the composition according to the present invention contains genes, proteins, and growth factors related to the proliferation, differentiation and regeneration of stem cells, antibiotics, serum, and harmful factors of the culture medium are not included, so existing anti-inflammatory agents, stem cells Compared with therapeutic agents or exosomes, there is an advantage of having a better therapeutic effect and minimizing side effects at the same time.