EXPRESSION VECTOR BASED ON ADENO-ASSOCIATED VIRUS WITH PROTECTIVE PROPERTIES AGAINST INTOXICATION CAUSED BY BOTULINUM NEUROTOXIN TYPE A

摘要

FIELD: biotechnology, immunology and microbiology.;SUBSTANCE: inventions group relates to biotechnology, immunology and microbiology. An expression vector based on an adeno-associated virus with an embedded genetic construct containing the nucleotide sequence SEQ ID NO:2 encoding a recombinant antibody SEQ ID NO:1 was created, and the use of this vector for the prevention of intoxication caused by botulinum neurotoxin type A was proposed.;EFFECT: inventions group provides the creation of a recombinant viral vector that has a lower inflammatory potential and a longer time interval of protective activity.;6 cl, 9 dwg, 8 ex