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IMMUNOSUPPRESSANT DRUG RESISTANT ARMORED TCR T CELLS FOR IMMUNE-THERAPY OF ORGAN TRANSPLANT PATIENTS
IMMUNOSUPPRESSANT DRUG RESISTANT ARMORED TCR T CELLS FOR IMMUNE-THERAPY OF ORGAN TRANSPLANT PATIENTS
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机译:免疫抑制剂耐药装甲TCR T细胞在器官移植患者免疫治疗中的应用
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摘要
Described are novel immunosuppressant drug resistant armored (IDRA) T cells that co-express an exogenous T cell receptor (TCR) and one or more exogenous inhibitors of an immunosuppressant. The TCR can bind to an antigen expressed by a tumor cell or virally infected cell. Also described are methods of producing the modified T cell, and methods of treating a subject using the modified T cells.
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