IMMUNOSUPPRESSANT DRUG RESISTANT ARMORED TCR T CELLS FOR IMMUNE-THERAPY OF ORGAN TRANSPLANT PATIENTS

摘要

Described are novel immunosuppressant drug resistant armored (IDRA) T cells that co-express an exogenous T cell receptor (TCR) and one or more exogenous inhibitors of an immunosuppressant. The TCR can bind to an antigen expressed by a tumor cell or virally infected cell. Also described are methods of producing the modified T cell, and methods of treating a subject using the modified T cells.