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IMMUNOSUPPRESSANT DRUG RESISTANT ARMORED TCR T CELLS FOR IMMUNE-THERAPY OF ORGAN TRANSPLANT PATIENTS

机译:免疫抑制剂耐药装甲TCR T细胞在器官移植患者免疫治疗中的应用

摘要

Described are novel immunosuppressant drug resistant armored (IDRA) T cells that co-express an exogenous T cell receptor (TCR) and one or more exogenous inhibitors of an immunosuppressant. The TCR can bind to an antigen expressed by a tumor cell or virally infected cell. Also described are methods of producing the modified T cell, and methods of treating a subject using the modified T cells.
机译:描述了共同表达外源性T细胞受体(TCR)和一种或多种免疫抑制剂的新型免疫抑制剂耐药装甲(IDRA)T细胞。TCR可与肿瘤细胞或病毒感染细胞表达的抗原结合。还描述了产生经修饰的T细胞的方法,以及使用经修饰的T细胞治疗受试者的方法。

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