首页> 外国专利> METHOD FOR DIAGNOSING NEUROIMMUNE DISORDERS IN YOUNG CHILDREN WITH EPILEPSY

METHOD FOR DIAGNOSING NEUROIMMUNE DISORDERS IN YOUNG CHILDREN WITH EPILEPSY

机译:癫痫患儿神经免疫障碍的诊断方法

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to neurology, and can be used to diagnose neuroimmune disorders in young children with epilepsy. The child's blood serum is examined. In full-term newborns and children at the 1st year of life in the first month, at 3 and 6 months, the level of antibodies to myelin basic protein (AB to MBP) and antibodies to myelin-associated glycoprotein (AB to MAG) are determined in the blood serum. When the concentration of antibodies to myelin basic protein is 1.5 conventional optical density units (o.d.c.u.) and higher, and antibodies to myelin-associated glycoprotein are 172.4 pg/ml and higher, the development of neuroimmune disorders is diagnosed.;EFFECT: method provides the possibility of accurate specific diagnosis of neuroimmune disorders in children with epilepsy in the 1st year of life, which makes it possible to choose an adequate therapeutic and diagnostic tactics and improve the prognosis of the course of the disease, due to the early detection of brain-specific antibodies to MBP and MAG, which can serve as one of the prognostically significant tools for the occurrence of neuroimmune disorders in epilepsy in children.;1 cl, 1 tbl, 3 ex
机译:领域:医学。;物质:本发明涉及医学,即神经学,可用于诊断癫痫患儿的神经免疫障碍。检查孩子的血清。在足月新生儿和1岁儿童的第一个月、第3个月和第6个月,血清中测定髓鞘碱性蛋白抗体(AB-MBP)和髓鞘相关糖蛋白抗体(AB-MAG)的水平。当髓鞘碱性蛋白抗体浓度为1.5个常规光密度单位(o.d.c.u.)及以上,髓鞘相关糖蛋白抗体浓度为172.4 pg/ml及以上时,诊断为神经免疫疾病的发展。;效果:该方法为1岁癫痫患儿的神经免疫疾病提供了准确特异性诊断的可能性,由于早期检测到MBP和MAG的大脑特异性抗体,因此有可能选择适当的治疗和诊断策略,并改善病程的预后,这可以作为预测儿童癫痫神经免疫紊乱发生的重要工具之一。;1个cl,1个tbl,3个ex

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