Cardiomyocyte aggregate production technology that improves survival in cryopreservation and hypoxia

摘要

The present invention relates to a method for improving the long-term storage efficiency of myocardial cell aggregates. Therefore, since the myocardial cell aggregates can be cryopreserved by using the method of the present invention, organoid preparation using totipotent stem cells and differentiation can be performed. In addition to expanding the scope of research on 3D cell structures such as the development of new drugs using organoids, the cell viability in the hypoxic state that occurs after in-vivo transplantation is improved, and it can be usefully used for related technologies such as the development of cell therapy agents. Be expected. [Selection diagram] FIG. 20