THERAPEUTIC TRANSDERMAL BIOREACTOR OR TRAP PATCH FOR DIABETES, PHENYLKETONURIA, AUTOIMMUNE, HYPERCHOLESTERINAEMIA AND OTHER DISORDERS

摘要

A transdermal patch comprising: a microneedle in a protruding position, protruding from the transdermal patch; and immobilised functional molecules; wherein a fluid path is provided between the distal tip of the microneedle and the immobilised functional molecules; and the functional molecules are selected to interact with selected target molecules so as to convert or trap said target molecules. The device intends to dynamically curb the postprandial insulin spike offering an unprecedented therapeutic effect for diabetes and obesity with significant benefits in morbidity and without strict diet. The device offers unprecedented phenylketonuria management that removes the burden of strict diet. The device offers easy removal of autoantibodies, low density lipoprotein and other pathogenic molecules. The device can be used in any disorder that requires enzymatic replacement or elimination of pathogenic molecules via biochemical conversion or trapping.