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SOLUBLE ALKALINE PHOSPHATASE CONSTRUCTS AND EXPRESSION VECTORS INCLUDING A POLYNUCLEOTIDE ENCODING FOR SOLUBLE ALKALINE PHOSPHATASE CONSTRUCTS
SOLUBLE ALKALINE PHOSPHATASE CONSTRUCTS AND EXPRESSION VECTORS INCLUDING A POLYNUCLEOTIDE ENCODING FOR SOLUBLE ALKALINE PHOSPHATASE CONSTRUCTS
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机译:可溶性碱性磷酸酶构建体和表达载体,包括编码可溶性碱性磷酸酶构建体的多核苷酸
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摘要
The present disclosure is directed to polypeptides, such as polypeptides comprising an alkaline phosphatase and a bone-targeting moiety. Also disclosed are expression vectors, such as lentiviral expression vectors, including a nucleotide sequence encoding a polypeptide. Also disclosed are methods of treating hypophosphatasia or treating, mitigating, or preventing one or more symptoms of hypophosphatasia by administering to a subject in need of treatment thereof the disclosed polypeptides or host cells transduced to express any of the disclosed polypeptides.
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