Use of small molecule glycosidically bound terminal galactosides and fucosides to bind toxins acting as galectin in the treatment of poisoning, particularly in the case of ricin poisoning

摘要

The invention relates to the use of low-molecular glycosidic compounds with terminal D-galactose and L-fucose in the treatment of intoxications with ricin. The identified compounds form a lectin bond with the B chain of the ricin and thereby prevent further endocytosis of the toxins. The compounds should be ingested as early as possible after incorporation of the toxin and can also be used preventively. The groups bonded to the D-galactose and L-fucose can be other saccharides (e.g. fructose), polyalcohols (e.g. sorbitol), diacyl-glycerides or flavonoids (e.g. quercetin). Galactose-heteropolysaccharide hydrolysates such as guar gum flour can also be used. The identified compounds can be used for oral, pulmonary and systemic intoxications. They should be used in corresponding pharmaceutical forms of administration. The compounds are dosed in molar excess.