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PROVISION OF MALONYL-COA IN CORYNEFORM BACTERIA AND METHOD FOR PRODUCING POLYPHENOLES AND POLYKETIDES WITH CORYNEFORM BACTERIA
PROVISION OF MALONYL-COA IN CORYNEFORM BACTERIA AND METHOD FOR PRODUCING POLYPHENOLES AND POLYKETIDES WITH CORYNEFORM BACTERIA
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机译:在棒状细菌中提供丙二酰-CoA及其用棒状细菌生产多酚和聚酮化合物的方法
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摘要
A coryneform bacteria cell with an increased provision of Malonyl-CoA compared to its archetype, wherein the regulation and/or expression of one or more of genes fasB, gltA, accBC and accD1, and/or the functionality of the enzyme encoded by each gene is modified in a targeted manner. The cell may have one or more targeted modifications, including reduced or eliminated functionality of the fatty acid synthase FasB, mutation or partial or complete deletion of the fatty acid synthase encoding gene fasB, and/or reduced functionality of the promoter operatively linked to the citrate synthase gene gtIA, among other targeted modifications.
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