Provided is a composition for alleviating fatigue or enhancing exercise capability including extracts or fractions of Angelica gigas, Cnidium officinale, and Paeonia lactiflora as active ingredients. The composition including the extracts or fractions of Angelica gigas, Cnidium officinale, and Paeonia lactiflora as active ingredients may effectively alleviate fatigue accumulated in the body and enhance exercise capability by multilaterally controlling various factors involved in physical fatigue and/or enhancement of exercise capability. Specifically, the composition may effectively control the factors related to fatigue by increasing the expression level of HO-1 by activating the Nrf-2 pathway. Also, since extracts of natural plants or fractions thereof are used as active ingredients, the composition is completely harmless to the human body and may be used safely.
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