PERIPHERAL BLOOD TCR MARKER FOR BREAST CANCER AND DETECTION KIT AND APPLICATION THEREOF

摘要

Disclosed in the present invention are a peripheral blood TCR marker for breast cancer and a detection kit and an application thereof, the marker comprising at least one of the proteins shown in SEQ ID NO.1-100. The present invention is based on a high throughput sequencing method, and only a small amount of peripheral blood needs to be taken; RNA is extracted, an immunoassay library is established by means of processing the samples, and high throughput sequencing and TCR data analysis are performed, first determining characteristic TCR sequences in breast cancer peripheral blood, and then comparing the test result of a sample to be tested with the characteristic TCR sequences to determine whether there is breast cancer. The present invention can simultaneously compare a large number of breast cancer-specific TCR sequences, having higher specificity and accuracy compared to individual detection of one or several markers, and thereby improving diagnosis efficiency.