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METHOD FOR PREPARING PREGABALIN INTERMEDIATE (R)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID

机译：制备普瑞巴林中间体（R）-3-（氨基甲甲基甲基）-5-甲基己酸的方法

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摘要

A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting compound (I) 3-isobutylglutaric acid, as a raw material, with a nitrogen-containing agent to produce compound (II) 3-isobutylglutarimide; and performing stereoselective ring-opening of compound (II) under the action of a biological enzyme to produce compound (III) (R)-3-(carbamoylmethyl)-5-methylhexanoic acid:

机译：一种用生物酶方法制备普瑞巴林手性中间体（R）-3-（氨基甲甲基）-5-甲基己酸的方法。特别地，该方法包括：使化合物（I）3-异丁基丙酸作为原料反应，用含氮剂制备化合物（II）3-异丁基乙烯酰亚胺; 在生物酶的作用下进行化合物（II）的立体选择性环，以产生化合物（III）（R）-3-（氨基甲酰甲基）-5-甲基己酸：

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公开/公告号EP3805199A4

专利类型
公开/公告日2022-01-19

原文格式PDF
申请/专利权人 ZHEJIANG HUAHAI PHARMACEUTICAL CO. LTD;
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申请/专利号EP20180921480
发明设计人 YANG CHANGMING;GUO PAN;WANG YIFENG;ZHANG WENLING;WANG PENG;
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申请日2018-06-06
分类号C12P13/02;C07C227/04;C07C227/32;C07C229/08;
国家 EP
入库时间 2022-08-24 23:28:43

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