Extracellular vesicles for vaccine delivery

摘要

The present disclosure relates to extracellular vesicles (EVs), eg, exosomes, comprising a payload (eg, antigen, adjuvant and/or immune modulator) and/or a targeting moiety. Also disclosed herein are methods of making EVs (eg, exosomes) and treating and/or preventing a disease or disorder, eg, cancer, graft versus host disease (GvHD), autoimmune disease, infectious disease or fibrotic disease. A method of using EVs (eg, exosomes) is provided for