Customized hypoimmune nanovesicle delivery system for cancer tumors

摘要

Hypoimmunogenically induced pluripotent stem cell (iPSC)-derived biomimetic comprising a customized chimeric antigen receptor (CAR) capable of recognizing a target biomarker via an antibody fragment scFV region or by a viral epitope recognition receptor (VERR) Nanovesicles (Hypo-BioNV). Method for producing hypo-bio NV. A method of treating an individual having cancer by administering to the individual hypo-BioNV, targeting the cancer cells, and treating the cancer. A method of targeting a cell in a subject by administering the hypo-BioNV to the subject and targeting the cell to be destroyed or treated.