A pharmaceutical composition containing cell-transducing PGAM5 fusion protein for preventing or treating motor neuronal disorder

摘要

Challenge: To provide a drug for the treatment of neurological diseases with few or no side effects and excellent efficacy. Solution: The present invention relates to a pharmaceutical composition for the treatment of neurological diseases comprising a cell-permeable PGAM5 (phosphoglycerate mutase 5) fusion protein, wherein the PGAM5 fusion protein permeated into the cell increased the cell viability against hydrogen peroxide toxicity. , reduced intracellular reactive oxygen species levels and hydrogen peroxide-induced DNA fragmentation. These results suggest that the PGAM5 fusion protein has a protective effect against apoptosis and has a therapeutic effect to protect nerve cells from neurological damage.