Novel enantioenriched bisindolylmethane sulfamate derivatives and the compositions for treating neuropathy comprising thereof

摘要

The present invention relates to a compound represented by Formula 1 or a pharmaceutically acceptable salt thereof; a method for preparing the compound; And it relates to a pharmaceutical composition for preventing or treating diabetic neuropathy comprising the compound or a pharmaceutically acceptable salt thereof as an active ingredient. The novel optically active bisindorylmethane sulfamate derivative compound of the present invention acts on semi-cells to inhibit the neuroaxon degeneration of Schwann cells and dedifferentiation of Schwann cells, thereby preventing the degeneration of peripheral nerves and effectively preventing or preventing diabetic neuropathy. could be used for treatment. In addition, the method for preparing the compound according to the present invention enables eco-friendly production at a lower cost compared to the case of using a conventional metal catalyst by using an optically active organic catalyst.