ACTIVE SUBSTANCE AGAINST PROTOZOA

摘要

The present invention relates to active substances against protozoa, especially against Plasmodium spp., e.g. against Plasmodium falciparum, Plasmodium vivax, P. malariae, P. ovale, P. knowlesi, against Toxoplasma spp., e.g. Toxoplasma gondii, against Entamoeba histolytica, against Naegleria fowleri, and relates to a method of treatment and/or prophylaxis of an infection by a protozoon. The active substances are suitable for use in the treatment of and/or for use in prophylaxis of an infection by a protozoon. The active substances have the advantage of having activity against wild-type protozoa, especially against Plasmodium spp. and against Toxoplasma spp. and against Entamoeba histolytica and against Naegleria fowleri, and of having activity also against a mutant of P. falciparum that has been identified as resistant against other anti-malarial active substances.