Hepatitis B virus (HBV) iRNA composition and its usage

摘要

PROBLEM TO BE SOLVED: To use an RNAi agent targeting the hepatitis B virus (HBV) genome, for example, a double-stranded RNAi agent, and such an RNAi agent for inhibiting the expression of one or more HBV genes, and HBV infection and / Or provide a method of treating a subject having an HBV-related disorder, such as a chronic hepatitis B infection. A double-stranded RNAi agent for inhibiting the expression of hepatitis B virus (HBV) in cells, wherein the double-stranded RNAi agent has a sense strand and an antisense strand forming a double-stranded region. Containing, the sense strand contained a particular nucleotide sequence, substantially all of the nucleotides of the sense strand and substantially all of the nucleotides of the antisense strand were modified nucleotides, and the sense strand was attached at the 3'end. A double-stranded RNAi agent conjugated to a ligand and the ligand is one or more GalNAc derivatives linked via a divalent or trivalent branched strand linker. [Selection diagram] Fig. 1