Preparation of glucagon-like peptide-2 (GLP-2) analog

摘要

Described are liquid formulations of GLP-2 analogs that are suitable for long-term storage as a liquid and / or are particularly suitable for delivery by a drug delivery device. Also described is a solid composition comprising an acetate of a glucagon-like peptide 2 (GLP-2) analog useful for making liquid formulations. The development of these liquid formulations is that the acetate present in the formulation derived from the GLP-2 analog affects the viscosity of the formulation, and the GLP-2 analog is shared during long-term storage at 2-8 ° C. The concentration dependence of the binding oligomer formation is inversely proportional to the increase in the concentration of the GLP-2 analog, and the GLP-2 analog used in the pharmaceutical product is a reconstituted powder or freeze-dried GLP-. It is based on the finding that the two compositions are not compatible with the phosphate buffer commonly used in the prior art.