A non-invasive analyte sensor system includes an antenna/detector array having at least one transmit antenna/element and at least one receive antenna/element, wherein the at least one transmit antenna/element and the at least one receive antenna/element are less than 95% coupled to one another, or less than 90% coupled to one another, or less than 85% coupled to one another, or less than 75% coupled to one another. The at least one transmit antenna/element transmits a transmit signal in a radio or microwave frequency range of the electromagnetic spectrum into a target containing an analyte of interest, and the at least one receive antenna/element detects a response resulting from transmission of the transmit signal by the at least one transmit antenna/element into the target.
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