SELF-ASSEMBLED SHORT PEPTIDE BASED ON ATYPICAL HYDROPHOBIC AMINO ACID AND USE THEREOF

摘要

A short peptide and the use thereof as a carrier of a hydrophobic drug. The amino acid sequence of the short peptide involved is composed of 2-10 glutamines and 0-5 amino acids X, wherein X can be tyrosine, threonine, glycine, asparagine, serine, alanine, valine, phenylalanine, leucine, isoleucine or tryptophan. The short-chain polypeptide can load a plurality of hydrophobic drugs by means of a molecular self-assembly mechanism to form nanospheres with uniform particle sizes, so that the drugs are effectively transferred into cells or tissues to exert the effect of the drug, and the short-chain polypeptide is safe, free of obvious cytotoxicity and simple in preparation process, and is a hydrophobic drug carrier with great development prospects.