The present invention provides a method for obtaining an aptamer capable of binding to a target, comprising the steps of generating a library of candidate aptamers of various sizes, incubating the candidate aptamers with the target and selecting the candidate aptamers that bind to the target. The present invention also relates to a kit for selection of a DNA or RNA aptamer. Further, the present invention relates to a method of diagnosing or treating a disorder or disease by generating and selecting aptamers against a target that characterizes the disease or disorder. The present invention also relates to a method of detecting the presence or absence of a target in a sample. Furthermore, the present invention relates to aptamers or a library of aptamers.
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