The present invention features synthesis, characterization, and use of compositions comprising a triazabutadiene scaffold with a carbon-carbon bond for attachment of an aryl group. Methods of synthesis include Suzuki coupling for installation of the carbon-carbon bond to the triazabutadiene scaffold. The carbon-carbon bond allows for attachment of a variety of aryl groups. The aryl groups may remain protected by the triazabutadiene scaffold and reserved for future use. The methods and compositions herein may be used for a variety of applications including but not limited to protein labeling, synthesis of pro-drugs, probe synthesis, drug discovery applications, mass spectrometry, fluorescence microscopy, synthesis of various conjugate molecules, etc.
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