Iterative protein structure prediction using gradient of quality scores

摘要

A method, system and apparatus comprising a computer program encoded to a computer storage medium for performing protein structure prediction and protein domain segmentation.In one aspect,How toProvide steps for generating multiple predictive structures of proteinsThe step of generating the predicted structure of protein isA step of updating an initial value of a plurality of structural parameters of a protein is provided;To updateIn each of a plurality of update iterationsDetermining the slope of the quality score for the current value of the structural parameter for the current value of the structural parameter andA gradient is used to update the current value of the structural parameter.