Modified Monocytes/Macrophage Expressing Chimeric Antigen Receptors and Uses Thereof
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机译:表达嵌合抗原受体的改性单核细胞/巨噬细胞及其用途
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摘要
The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric antigen receptor in a monocyte, macrophage or dendritic cell, the modified cell is recruited to the tumor microenvironment where it acts as a potent immune effector by infiltrating the tumor and killing the target cells. One aspect includes a modified cell and pharmaceutical compositions comprising the modified cell for adoptive cell therapy and treating a disease or condition associated with immunosuppression.
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