A novel diagnostically relevant autoantibody

摘要

The present inventions relates to a method for diagnosing a disease, preferably a disease associated with neurological symptoms, comprising the step detecting in a sample from a patient an autoantibody binding to NBC1; an immobilized polypeptide comprising NBC1 or a variant thereof, preferably immobilized on a solid carrier; a use of a polypeptide comprising NBC1 or a variant thereof for the diagnosis of a disease, preferably comprising the step detecting an autoantibody binding to NBC1; a polypeptide comprising NBC1 or a variant thereof, preferably immobilized, more preferably on a solid carrier, for use in the treatment of a disease; an autoantibody, preferably an isolated autoantibody, binding to a polypeptide comprising NBC1, wherein the autoantibody is preferably in complex with said polypeptide, preferably for use in the diagnosis of a disease; a method for isolating an autoantibody binding to NBC1, comprising the steps contacting a sample comprising the autoantibody with a polypeptide comprising NBC1 or a variant thereof under conditions compatible with formation of a complex, wherein said autoantibody binds to said polypeptide, isolating the complex formed, dissociating the complex isolated in step b), and separating the autoantibody from the polypeptide; a pharmaceutical composition comprising a polypeptide comprising NBC1 or a variant thereof, preferably for the treatment of a disease; a medical or diagnostic device comprising a polypeptide comprising NBC1 or a variant thereof; and a test kit for the diagnosis of a disease, comprising a polypeptide comprising NBC1 or a variant thereof, wherein preferably the test kit comprises, in addition, a means for detecting the complex comprising an autoantibody binding to NBC1.