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DEVICE AND METHOD FOR MOTILITY-BASED LABEL-FREE DETECTION OF MOTILE OBJECTS IN A FLUID SAMPLE
DEVICE AND METHOD FOR MOTILITY-BASED LABEL-FREE DETECTION OF MOTILE OBJECTS IN A FLUID SAMPLE
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机译:基于运动的可动力学的无动机物体的无动机的装置和方法
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摘要
Systems and methods for detecting motile objects (e.g., parasites) in a fluid sample by utilizing the locomotion of the parasites as a specific biomarker and endogenous contrast mechanism. The imaging platform includes one or more substantially optically transparent sample holders. The imaging platform has a moveable scanning head containing light sources and corresponding image sensor(s) associated with the light source(s). The light source(s) are directed at a respective sample holder containing a sample and the respective image sensor(s) are positioned below a respective sample holder to capture time-varying holographic speckle patterns of the sample contained in the sample holder. The image sensor(s). A computing device is configured to receive time-varying holographic speckle pattern image sequences obtained by the image sensor(s). The computing device generates a 3D contrast map of motile objects within the sample use deep learning-based classifier software to identify the motile objects.
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