Diagnostic set of reagents for detecting chronic disease states from brain ischemia

摘要

The present invention relates to diagnostics, ie, reagent kits, rapid methods and devices for detecting the facts of chronic ischemia-related brain pathology. A particular feature of the present invention is the use of immunoreactive hybrid peptides produced as products of two fragments of the NMDA neuroreceptor subunit. Devices have been described that allow for quick and convenient testing of autoantibodies that recognize hybrid peptides in a subject's blood. The method for detecting autoantibodies is based on the principle of lateral flow immunochromatography. The present invention can be used in prophylactic health examinations (screening for chronic ischemia-related brain lesions) by general practitioners or neurologists at the pre-hospital stage and in individuals with cranial cerebral injuries. Decompensated chronic cerebral ischemia can be detected in neurosurgery and sports medicine for the diagnosis of cerebral ischemia.