Polycyclic compounds and methods for targeted degradation of rapidly progressive fibrosarcoma polypeptides

摘要

The present disclosure demonstrates the usefulness of a regulatory protein for raptically accelerated fibrosarcoma (RAF, e.g., c-raf, A-Raf and / or B-Raf)Relating to ulm-l-ptm of bifunctional compounds. In particular, the present disclosure degrades the target proteinA target protein is placed close to the ubiquitin ligase to bring about inhibitionA mouse double minute homologue 2 that binds to the phylepel, celleton, insulators of Apotosis proteins, or each E3 ubiquitin ligase at one end, in one end of RigaA bifunctional compound containing a donor and binding to the target protein RAF at the other endTarget. This disclosure presents extensive pharmacological activity associated with the degradation / inhibition of target proteins. The disease or disorder resulting from the aggregation or accumulation of the target protein or the constitutive activation of the target protein is treated or prevented using the compounds and compositions of the present disclosure.