Targeted radionuclide treatment and molecular imaging and fine treatment of HER2 + cancer and other neoplasms

摘要

Methods and compositions for treating, diagnosing, and stage classifying cancer, particularly in human breast cancer, gastric cancer, gastroesophageal cancer, ovarian cancer, pancreatic cancer and brain tumors and overexpressing the human epidermal growth factor receptor 2 protein (HER2 +) that may metastasize to the brain or other site.More specifically, the present invention targets a peptide of HER2 + cellsA second component for coupling metal to a complex via a ring structure (dota)And the third radioisotope componentA target radionuclide treatment (trnt) using the compound of the present invention having lu-177 and Ga-68 is providedThe embodiment further includes companion diagnosis.In an embodiment α V β 3 and α V β 5 IntegrinsHER2 +Vascular endothelial growth factorVitronectinFibronectinTennessinLilingIt also includes anti integrin fine medicine for cancer expressing kindrin and Tallinn.Trnt alone or standard treatment; May be administered in combination with immunooncology and / or chemotherapy, adjuvant or neoadjuvant.