Cyclic dinucleotide analog, its pharmaceutical composition and use

摘要

It is an annular dinucleotide analog, its pharmaceutical composition and use.Cyclic dinucleotide analogs (I), their isomers, prodrugs, stable isotope derivatives, or pharmaceutically acceptable salts have the following structures.Cyclic dinucleotide analogues can be used as modulators of interferon gene stimulating factor stits and related signal pathways, and are associated with malignant tumors, inflammation, and autoimmune diseases Various types of diseases, including but not limited to infectious diseases, can be effectively treated and / or relaxed.The sting modulator can also be used as a vaccine adjuvant.1