BISPECIFIC IMMUNOTOXINS TARGETING HUMAN CD25+CCR4+ TUMORS AND REGULATORY T-CELLS

摘要

IL2-CCR4 bispecific immunotoxin, CCR4- IL2 bispecific immunotoxin, and methods of use thereof for treatment of refractory and recurrent human CD25+ and/or CCR4+ cutaneous T cell lymphoma, and other human CD25+ or CCR4+ tumors. The bispecific immunotoxin can be also used for broad cancer treatment via depleting CD25+ or CCR4+ Tregs.