ASSAYS TO DETECT COMPOUNDS THAT BIND THE SARS-COV-2 SPIKE PROTEIN

摘要

Microparticle-based in vitro assays that detect antibodies that bind the SARS-CoV-2 spike protein and that detect binding between the SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 (hACE2) are described. The assays can quantify inhibition of such binding by either human serum/plasma or drug candidates. The assay is compatible with high-throughput screening systems.