(5 s, 10s) - 10 - benzyl-16 methyl - 11,14-methyl-15,14,18-triox-15,17,19-trioxa-2,7,8-trithia-12-azheneicosan-5-aghenium (E) - 3-carboxylacrylate salt: an industrial process for the preparation of carboxylate

摘要

An industrial process for the preparation of the lower (5S, 10s) - 10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azanheneisan-5-aminium (E) - 3-carboxylate acrylate salt, which is fumarate;To obtain the desired productKinetic partitioningFormation of disulfide compoundsPeptide couplingIt includes an important continuous process, such as anion exchange reaction.Various parameters of synthesis are optimized to satisfy the requirements of industrial processes.No selection