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APTAMER-BASED SENSORS FOR DETECTION OF FENTANYL OPIOIDS
APTAMER-BASED SENSORS FOR DETECTION OF FENTANYL OPIOIDS
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机译:基于适体的基于芬太尼阿片类药物的传感器
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摘要
The subject invention provides materials and methods for single-step fluorescence and electrochemical detection of small molecules, e.g., fentanyl and its analogs, in a sample. The subjection invention provides nucleic acids materials, e.g., aptamers (nucleic acid oligonucleotides) that can bind to fentanyl and its analogs with nanomolar affinity and high specificity against illicit drugs, adulterants, and cutting agents commonly existing in seized samples. The method for detecting fentanyl and/or its analogs in a sample comprises contacting the sample with an aptamer-based sensor selective for fentanyl and its analogs, and sensitively, specifically, and rapidly detecting fentanyl and/or its analogs in the sample.
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