DUAL-ACTIVATING COSTIMULATORY MOLECULE RECEPTOR AND USE THEREOF

摘要

Provided are a dual-activating costimulatory molecule receptor and the use thereof. The dual-activating costimulatory molecule receptor comprises the following elements from the N-terminus to the C-terminus: a selectable signal peptide, a costimulatory signal molecule-activating single-chain antibody, an extracellular hinge area, a transmembrane region and an intracellular costimulatory signal molecule. The dual-activating costimulatory molecule receptor can produce a strong clustering effect when co-modifying T-cells with first-generation CAR-T comprising a first signal, can kill tumor cells, and at the same time, does not trigger a strong T-cell immunity or cause potentially serious toxic side effects.