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QUANTITATIVE MAPPING OF CHROMATIN ASSOCIATED PROTEINS
QUANTITATIVE MAPPING OF CHROMATIN ASSOCIATED PROTEINS
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机译:染色质相关蛋白的定量映射
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摘要
The present invention relates to DNA-barcoded recombinant nucleosomes and polynucleosomes that have been engineered for use as spike-in controls for the quantitative mapping of chromatin associated proteins using Chromatin ImmunoPrecipitation (ChIP) assays, tethered enzyme-based mapping assays, and other chromatin mapping assays. The invention further relates to methods of using the engineered DNA-barcoded recombinant nucleosomes in ChIP assays, tethered enzyme-based mapping assays, and other chromatin mapping assays.
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