Methods and Compositions for Modulating Peripheral Immune Function

摘要

To provide cell populations useful for modulating various peripheral immune functions, methods for preparing the cell populations, and methods for their use.SOLUTION: A composition is obtained by: (a) providing a culture of mesenchymal stem cells; (b) contacting the cell culture of step (a) with a polynucleotide comprising sequences encoding a Notch intracellular domain (NICD); (c) selecting cells that comprise the polynucleotide of step (b); and (d) further culturing the selected cells of step (c) in the absence of selection.SELECTED DRAWING: Figure 2