SYNTHESIS OF (2S,5R)-5-(2-CHLOROPHENYL)-1-(2'-METHOXY-1,1'-BIPHENYL-4-CARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID

摘要

The present invention relates to a process of manufacturing of (2S,5R)-5-(2- chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid (1), including the preparation of (2S,5R)-methyl 5-(2-chlorophenyl)pyrrolidine-2- carboxylate hydrochloride (6.HCl) as intermediate of synthesis: